We design biologically equivalent gelatin mixtures
We use tailored gels to replicate the dielectric properties (conductivity and permittivity) of various tissues. This allows us to replicate in vivo conditions for more accurate radio frequency coil and pulse sequence development. We've calculated the gel recipe for a wide-range of tissues and operating frequencies.
We use a radio frequency signal or "Pilot Tone" to provide tracking information to sort motion-state k-space lines during simultaneous MRI/PET scans
The introduction of simultaneous MR/PET scanners has, for the first time, provided a synergistic imaging platform where the simultaneously acquired data can be used to provide significant improvements in image quality, interpretation and quantification. Motion correction stands as one application where immediate benefit can be garnered from the use of such synergies. We use a synthesizer to generate a reference signal (the pilot tone) to provide a signature of coil loading variations that identifies individual motion states throughout the duration of a MR/PET examination.
We build fixtures such as radio frequency coil interfaces for parallel transmission and MRI-compatible ergometers to quantify pedal flexion exercise.
Susceptibility mapping is a new way to characterize tissue by differentiating, for example, iron, calcium, and oxygen, as well as to quantify contrast agents in angiography, perfusion, or labeled cells.
The magnetic property susceptibility can be mapped using simple gradient echo MRI data. The magnetic field associated with each region of unit susceptibility is calculated according to Maxwell Equation approximations. The calculated field model forms an over-determined system that allows robust inversion through least squares fitting of the measured field to estimate susceptibility and chemical shifts. Quantitative Susceptibility Mapping can simultaneously and accurately estimate the susceptibility and chemical shift of various diamagnetic and paramagnetic materials. Notably, susceptibility can be determined in regions with no or low signal (for example air or regions of short T2*) that opens the way to cortical bone density characterization.